Recombinant Mouse Flt-3 Ligand/FLT3L Protein, Active
Description
Product Overview
| Product Name | Recombinant Mouse Flt-3 Ligand/FLT3L Protein |
| Target Symbol | FLT3LG |
| Alternative Names | fms-like Tyrosine Kinase 3 Ligand, FLT3L, Flt3 Ligand, FLG3L, SL Cytokine |
| Accession Number | P49771 |
| Expression System | E. coli. |
| Sequence | Gly27-Arg188 |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Activity | Determined by in-house activity assay |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | Available Upon Request |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Flt-3L (Fms-related tyrosine kinase 3 ligand) is a protein that plays a role in regulating the survival, expansion and differentiation of hematopoietic stem cells (HSCs), including progenitor cells in both the lymphoid and myeloid lineages. Flt-3L also promotes expansion and differentiation of dendritic cells, NK cells and B cells. Flt-3L is expressed as both membrane-bound and soluble isoforms, both of which initiate signaling through binding to the receptor, Flt3 (CD135/Flk2). |
| Tissue Specificity | Flt-3L expression has been reported in bone marrow stromal cells, brain, thymus, placenta, spleen, testes, and lymph nodes. |
| Cellular Localization | Membrane-bound and cleaved soluble protein forms |
| Involvement In Disease | Dysregulation of Flt-3L is associated with aplastic anemia and acute myeloid leukemia. |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0060 |
| Size | 100ug |
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