Recombinant Human Noggin/NOG Protein, Active
Description
Product Overview
| Product Name | Recombinant Human Noggin/NOG Protein |
| Target Symbol | NOG |
| Alternative Names | NOG, SYNS1, SYM1, Symphalangism 1 (proximal), SYNS1A, Synostoses (multiple) syndrome 1 |
| Accession Number | Q13253 |
| Expression System | Mammalian cell line. |
| Molecular Weight | 23 kDa (monomer, predicted) |
| Sequence | Gnl28-Cys232 |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Activity | Determined by in-house activity assay |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | Available Upon Request |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Noggin plays a crucial role in embryonic development and maintenance of various tissues. Its primary function is to inhibit the activity of bone morphogenetic proteins (BMPs) by directly binding to BMPs to block the interaction with the heteromeric BMP receptor complex. By inhibiting BMP signaling, Noggin helps to regulate processes such as cell differentiation, proliferation, and apoptosis (programmed cell death) during embryonic development. In particular, Noggin is involved in the formation of various structures in the embryo, including the central nervous system, limbs, and skeletal system. It helps to ensure proper patterning and growth of these structures by modulating BMP signaling gradients. Outside of embryonic development, Noggin also plays a role in tissue regeneration and repair in adults. In cell culture and organoid culture applications, Noggin maintains pluripotency and/or modulates differentiation. |
| Tissue Specificity | During early embryonic development, Noggin is expressed in the embryonic ectoderm, including the neural tube, where it plays a critical role in regulating the formation and patterning of the central nervous system. Noggin continues to be expressed in the CNS throughout development and into adulthood. It is involved in regulating neural stem cell proliferation and differentiation and has been implicated in processes such as neurogenesis and synaptic plasticity. Noggin is expressed in the developing limb buds and developing skeletal tissues, including cartilage and bone, where it regulates bone formation and remodeling. Noggin expression has also been reported in other tissues and organs, including the kidneys, lungs, heart, and reproductive organs, where it may play various roles in development, homeostasis, and regeneration. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Dysregulation of Noggin has been implicated in the pathogenesis of osteoarthritis, skeletal dysplasias, fibrodysplasia ossificans progressiva (FOP), proximal symphalangism 1 (SYM1), multiple synostoses syndrome 1 (SYNS1) and neural tube defects. |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0043 |
| Size | 100ug |
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