Recombinant Human/Mouse/Rat BDNF Protein, Active, Low Endotoxin
Description
Product Overview
| Product Name | Recombinant Human/Mouse/Rat BDNF Protein |
| Target Symbol | BDNF |
| Alternative Names | Brain-derived Neurotrophic Factor, Neurotrophin, Abrineurin, ANON2, BULN2 |
| Accession Number | P23560 |
| Expression System | E. coli. |
| Molecular Weight | 13.6 kDa (predicted) |
| Sequence | His129-Arg247, with an N-terminal Met |
| Purity | >98% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Activity | Determined by the ability to promote proliferation of neuroblastoma cells.The ED50 for this effect is typically <40 ng/mL. |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | <0.005 EU per 1 μg of the protein as determined by the LAL method |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Brain-Derived Neurotrophic Factor (BDNF) is a protein that plays a crucial role in the development, growth, maintenance, and survival of neurons. BDNF regulates neurogenesis of new neurons from neural stem cells by promoting axon and dendritic growth. BDNF enhances neuroprotection and regulates synaptic plasticity in mature neurons, thus affecting aspects of mood regulation, learning, memory and other cognitive functions. BDNF binds to TrkB as the high affinity signaling receptor, but association with the low-affinity p75-NTR has been reported. |
| Tissue Specificity | BDNF expression has been reported in brain (hippocampus, cortex, and basal forebrain), peripheral nerves, heart, skeletal muscle, adipose tissue, liver, thymus, and lung. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Dysregulation of BDNF has been associated with bipolar disorder, depression, Alzheimer’s disease, Parkinson’s disease, and epilepsy. |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0048UL |
| Size | 100ug |
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