Recombinant Human LIF Protein, Active
Description
Product Overview
| Product Name | Recombinant Human LIF Protein |
| Target Symbol | LIF |
| Alternative Names | Leukemia Inhibitory Factor, Differentiation Inhibitory Activity, Cholinergic Differentiation Factor, Differentiation-Stimulating Factor, Hepatocyte-Stimulating Factor III, Differentiation-Inducing Factor, Melanoma-Derived LPL Inhibitor, D Factor, Emfilermin, HILDA, CDF, DIA, MLPLI |
| Accession Number | P15018 |
| Expression System | E. coli. |
| Molecular Weight | 19.7 kDa |
| Sequence | Ser23-Phe202 |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Activity | Determined by in-house activity assay |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | Available Upon Request |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | LIF (Leukemia Inhibitory Factor) is a protein that plays multiple roles across regulation of stem cell differentiation, immune response, reproductive function and neuroprotection. LIF is typically associated with the maintenance of pluripotency in embryonic stem cells in cell culture. LIF production by CD4 T cells and Regulatory (Treg) Cells have been shown to suppress Th17 differentiation. Likewise, LIF expressed by tumors have an immunosuppressive effect. In uterine tissues, LIF facilitates embryo attachment to endometrial tissue. LIF downregulates inflammation and promotes the neuroprotective response during injury of neurons, thereby limiting neurodegeneration. LIF signaling occurs by binding to LIF Receptor (LIFR/CD118) heterodimerized to gp130 (CD130). |
| Tissue Specificity | LIF expression has been identified in brain (astrocytes, microglia), neurons, liver, skeletal muscle tissue, endometrium, thymus and lung. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Dysregulation of LIF has been associated with endometriosis, ectopic pregnancy, rheumatoid arthritis, inflammatory bowel disease (IBD), asthma, multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, myeloid leukemia, and cancers (breast cancer, prostate cancer, pancreatic, ovarian cancer). |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0042 |
| Size | 100ug |
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