Recombinant Human IL-4 Protein, Active, Low Endotoxin
Description
Product Overview
| Product Name | Recombinant Human IL-4 Protein |
| Target Symbol | IL4 |
| Alternative Names | Interleukin 4, Lymphocyte Stimulatory Factor 1, B-Cell Stimulatory Factor 1, B Cell Growth Factor 1, BCGF1, BSF1, Binetrakin, Pitrakinra, MGC79402, IL4e12, IgG1 Induction Factor |
| Accession Number | P05112 |
| Expression System | E.Coli. |
| Molecular Weight | 15.1 kDa (monomer, predicted) |
| Sequence | His25-Ser153, with an N-terminal Met |
| Purity | >97% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining. |
| Activity | Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <100 pg/mL. |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | <0.001 EU/1ug of the protein as determined by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Interleukin-4 (IL-4) is a cytokine involved in the regulation of immune and inflammatory responses. It promotes the differentiation of naïve T cells into Th2 cells, which in turn stimulate B cells to upregulate IgE antibodies. IL-4 is produced by mast cells, eosinophils, basophils and committed Th2 cells. There are two cell-dependent receptor complexes, either a heterodimer of IL-4 R alpha (CD124) and the common gamma chain (CD132) associated with hematopoietic cells or a heterodimer of IL-4 R alpha and IL-13 R alpha 1 (CD213A1) associated with non-hematopoietic cells. |
| Tissue Specificity | IL-4 expression has been identified in lymph node and placenta. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Allergic inflammation, allergic rhinitis, asthma, atopic dermatitis, autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis), inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD). |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0015UL |
| Size | 100ug |
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