Recombinant Human IL-21 Protein, Active, Low Endotoxin
Description
Product Overview
| Product Name | Recombinant Human IL-21 Protein |
| Target Symbol | IL21 |
| Alternative Names | Interleukin 21, Za11, CVID11 |
| Accession Number | Q9HBE4 |
| Expression System | E.Coli. |
| Molecular Weight | 15.4 kDa (predicted) |
| Sequence | Gln32-Ser162, with an N-terminal Met |
| Purity | >98% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Activity | Measured by a dose-dependent induction of human IFN-gamma secretion by human natural killer lymphoma cells. The ED50 for this effect is typically <7 ng/mL. |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | <0.01 EU/1ug of the protein as determined by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Interleukin-21 (IL-21) is a cytokine that plays a role in coordinating immune responses and maintaining immune system balance. IL-21 is produced by NKT cells, Th17 cells and T follicular helper cells (Tfh). It functions in downregulating regulatory T (Treg) cells and modulating B cell activation and differentiation into plasma cells and memory B cells. Through the stimulation of NK cells and CD8 T cells, IL-21 is associated with antitumor activity. IL-21 signaling occurs through the heterodimer receptor complex of IL-21R (CD360) and the common gamma chain (CD132). |
| Tissue Specificity | IL-21 expression has been identified in spleen, lymph nodes, tonsils, thymus, gut-associated lymphoid tissue (GALT), mucosa-associated lymphoid tissue (MALT), skin, and liver. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Dysregulation of IL-21 is associated with autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD)), asthma, allergic rhinitis, psoriasis, and atopic dermatitis. |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0022UL |
| Size | 100ug |
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