Recombinant Human IL-13 Protein, Active, Low Endotoxin
Description
Product Overview
| Product Name | Recombinant Human IL-13 Protein |
| Target Symbol | IL13 |
| Alternative Names | Interleukin 13, IL13, P600, NC30, MGC116786, MGC116788, MGC116789 |
| Accession Number | AAK53823 |
| Expression System | E. coli. |
| Molecular Weight | 12.7 kDa (predicted) |
| Sequence | Ser19-Asn132, with an N-terminal Met |
| Purity | >98% by SDS-PAGE and quantitative densitometry by CoomassiePurity ® Blue staining |
| Activity | Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <2 ng/mL |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
| Endotoxin Level | <0.005 EU per 1 μg of the protein as determined by the LAL method |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. |
| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
| Target Function | Interleukin-13 (IL-13) is a cytokine primarily produced by T helper type 2 (Th2) cells, as well as other immune cells like mast cells, basophils, and eosinophils. It promotes the activation, differentiation, and survival of B cells, including Ig class switching. IL-13 enhances the survival and migration of epithelial cells in various organs, coupling this with its anti-parasitic Th2-mediated response in these organs. IL-13 signaling occurs when it binds IL13RA1 (CD213A1) which heterodimerizes with IL-4R alpha (CD124) to activate the JAK/STAT signal pathway. |
| Tissue Specificity | IL-13 expression has been identified in gastrointestinal and lung epithelial tissue. |
| Cellular Localization | Secreted protein |
| Involvement In Disease | Dysregulation of IL-13 is associated with asthma, allergic rhinitis, atopic dermatitis, scleroderma, inflammatory bowel disease (IBD), and allergic conjunctivitis. |
Intended use
Research Use Only
Specifications
| Product information | |
|---|---|
| Catalog number | BEP-0056UL |
| Size | 100ug |
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